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Immunoprecipitation studies revealed an increased association of FUS with XRCC1, LigIII, and PARP-1, but not with other base excision repair (BER) proteins in ALS patient-derived iPSC lines carrying FUS mutations (R521H and P525L)
This broader reduction is consistent with impaired CI assembly or stability, rather than an isolated subunit defect
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The recommendations are not equivalent to FDA approval and the agency is not required to follow the committee's advice
Possible side effects can include stomach upset, nerve damage, and skin conditions
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