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This dysregulation reduces serum iron and increases FTN stores, leading to a state of FID commonly observed in cancer patients and constituting a significant mechanism of cancer-related ID ( FPN is the only known cellular iron efflux protein, and its expression level plays a crucial role in regulating intracellular iron levels in tumor cells, which were found to be widely down-regulated in various tumors ( Genetic alterations in JHDMs [Jumonji-C (JmjC) domain-containing histone demethylases] have been identified in various human cancers

however, there were important limitations to consider, including small sample sizes, a lack of long-term observation, the use of a single species or strain, the lack of in-depth exploration of cellular or molecular mechanisms, failure to assess other aspects of reproductive function, a lack of validation of the clinical relevance, and a failure to consider individual differences in drug dosages

Therefore, SHANK3 mutations lead to various symptoms, including behavioral symptoms of ASD

96 UdovicicM.SeverM.KavurL.LoncaricK.BarisicI.BalenovicD.et al (2021)

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