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BMI 30 (or 27 with comorbidity)

Ubiquitin is a small protein with seven lysine sites (K6, K11, K27, K29, K33, K48, and K63), and K48-linked polyubiquitination mediates the degradation of proteins through the proteasome 43,44

While DSIP also seemed to encourage the growth of prolactin-producing cells, this might not be a direct result of DSIPs action

Referral to a registered dietitian is appropriate for patients with significant fatigue, rapid weight loss (more than 1-2% body weight per week), or concerns about nutritional adequacy