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However, administration of corticosterone along with withanolide A during exposure to hypobaric hypoxia significantly reduced the expression of Nrf2 as well as -GCLC m-RNA level in hippocampal region compared to only withanolide A treated hypoxic group

Finding your minimum effective dose Start by reducing your therapeutic dose by one step (typically 25 to 30%) and maintaining that level for four to six weeks