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Weeks Tirzepatide dose Notes 14 2.5 mg Initiation only (not for glucose/weight effect) 58 5 mg First maintenance option 912 7.5 mg Increase as tolerated 1316 10 mg Maintenance option 1720 12.5 mg Increase as tolerated 21+ 15 mg (max) Maximum maintenance dose These steps follow the Mounjaro FDA label and Zepbound FDA label

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355 However, due to our lack of understanding of exosome biology, structure, and biogenesis, the strategy of endogenous drug loading still requires further research and optimization

Medium alone was used to correct for background absorbance