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The acetylation of SP1 at K19 increases its protein stability and transcriptional activity, affecting polyamine metabolism through the ACSS2SP1SAT1 axis, and promoting the occurrence and progression of tumors

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8,9 Tyrosinase is the rate-limiting enzyme controlling the production of melanin and catalyzes the conversion of L-tyrosine supplied from the blood to 3,4-dihydroxyphenylalanine, then to dopaquinone

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