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Liu, L., Chen, J., Wang, L., Chen, C
15 The prohibition against producing drugs that are essentially copies of approved products protects the integrity and effectiveness of the new drug and abbreviated new drug approval processes
Methods Herein, we disclose a novel and efficient synthetic route to Semaglutide employing a rationally designed hexapeptide fragment, assembled via solid-phase peptide synthesis (SPPS) under carefully optimized conditions, which is subsequently introduced through fragment condensation at a late stage of the Semaglutide synthesis
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