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Recent studies show patients taking semaglutide and other semaglutide drugs have more than a fourfold higher risk of developing NAION compared to those not taking GLP-1 medications, and the World Health Organization issued warnings in June 2025 about this serious complication

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Their indications have since expanded to include obesity and metabolic syndrome X, fundamentally changing the medical paradigm

Tirzepatide can be taken using pre-filled injector pens (Mounjaro & Zebound) or single-use vials (Zepbound only, through Lilly Direct)

Semaglutide is primarily used to treat the following conditions: Before considering semaglutide treatment, there are several lifestyle changes and home remedies you can try to manage your blood sugar levels and weight: These lifestyle changes can significantly improve your health and may reduce the need for medical intervention