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Connectivity Map (CMap) A database developed at the Broad Institute (MIT/Harvard) that maps how thousands of compounds alter gene activity across the human genome
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Glutathione is a naturally occurring antioxidant found in your body, crucial for detoxifying cells , protecting against damage from toxins, and promoting healthy skin
Unlike genes, the number of known metabolites is relatively low (approximately 6500 distinct small molecules compared to around 25,000 genes, 100,000 transcripts, and 1 million proteins), allowing for high-resolution network analyses of cellular processes
Phosphorylation occurs on various cellular substrates on tyrosine residues including the IRS family and Src homology/collagen (SHC)-transforming family of proteins that mediate signals from the tyrosine kinases [132]
