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These compounds have been associated with a wide range of pharmacological activities, including antioxidative, radioprotective, antifatigue, hepatoprotective, immunomodulatory, neuroprotective, hypoglycemic, anti-osteoporotic, anticancer, and prebiotic activities [140]

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Consistent with this, use of a reducing source such as -mercaptoethanol allows reversal of xCT-KO phenotype, as it has been reported couple decades ago by Bannai's group ( in vivo can explain the discrepancy with in vitro phenotype