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Tirzepatide activates both GIP and GLP-1 receptors, which may produce different neurological effects than pure GLP-1 agonism

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Ive noticed that when GLP-1 is active, I feel less hungry and more satisfied after meals

For diabetes, NICE recommends continuing treatment if HbA1c reduces by at least 11 mmol/mol (1.0%) and weight decreases by at least 3% at 6 months

Raju K S, Alessandri G, Gullino P M