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Ire1 is a transmembrane protein that initiates the unfolded protein response upon accumulation of misfolded proteins in the ER lumen
This is even more important if you drink coffee as coffee can be a diuretic
Strategies to mitigate lean muscle loss while on treatment include optimising dietary protein, recognising that GLP-1 and GIP/GLP-1 receptor agonists may suppress appetite and substantially reduce overall energy intake, increasing the risk of inadequate protein consumption.260-262 Regular resistance exercise training can help preserve lean muscle mass during weight loss and should be performed on two or more days per week, where clinically appropriate.159 Dietary advice for people on incretin-based medications Incretin-based medications increase the risk of muscle loss, sarcopenic obesity and nutrient deficiencies
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