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Additionally, inflammatory cytokines and chemokines released by immune cells can activate signaling pathways that support tumor growth and survival [111]
Moreover, dysfunction of the ten-eleven translocation enzyme-ketoglutarate axis impairs active DNA demethylation, stabilizing disease-associated methylation patterns (70, 71)
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Tres ensayos clnicos aleatorizados realizados en 594 pacientes sin DM2, demostraron una prdida de peso promedio de -3,2kg (-4,3 a - 2,1kg), mientras que en 18 estudios que incluyeron pacientes con DM2 se observ una prdida de peso promedio de 2,8kg (-3,4 a -2,3kg)
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