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This combined pharmacotherapy resulted in a weight reduction of approximately 10.5%, compared to 2.5% for pramlintide alone after 24 weeks

Haidari H, Melguizo-Rodrguez L, Cowin AJ, Kopecki Z

Br Med J 2:478479 Rumack BH (1984) Acetaminophen overdose in young children

The FDA has also approved Wegovy to reduce cardiovascular risk in certain adults with cardiovascular disease and obesity or overweight

Nevertheless, pharmaceutical companies have pursued the twincretin concept, developing GLP-1/GIP dual agonists such as tirzepatide, an analogue biased in favour of GIP over GLP-1 activity [55], and NNC0090-2746, another analogue with balanced GLP-1 and GIP activity [56]