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Differences in skeletal maturation may further contribute, as females reach skeletal maturity earlier than males, rendering the timing of CR relative to growth phases critical for site-specific vulnerability
Regardless of phenotype, lifestyle modification, including dietary changes and increased physical activity, remains the foundational treatment (136)
Pre-and post-exercise nutrition Exercise, particularly resistance training, is strongly recommended during semaglutide use for muscle preservation
doi: 10.3389/fendo.2026.1787902 Received 14 January 2026 Revised 01 March 2026 Accepted 04 March 2026 Published 24 March 2026 Volume 17 - 2026 Edited by Sara F
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