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Constipation: Very common and intermittent, possibly related to significant reductions in food intake, especially fats and oils
Glutathione supplementation does not alter tirzepatide pharmacokinetics, but NAC in high doses (above 1800mg daily) can affect cysteine-dependent metabolic pathways that influence insulin sensitivity, which may interact with tirzepatide's glucose-lowering effects in patients with type 2 diabetes
10.7717/peerj.13082 62 LiuW.XuZ.LiH.GuoM.YangT.FengS.et al (2017)
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Goh V, Halligan S, Bartram CI
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