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O'Rahilly)
Abstract Background Glucagon-like peptide-1 (GLP-1) receptor agonists were recently approved for obesity treatment in children 1217 years by both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA)
The practical effect: the value of late-stage patent exclusivity (years 8-12 for small molecules, years 12-15 for biologics) has decreased relative to pre-IRA models
Robust LC-MS characterization supports biosimilar comparability, manufacturing consistency, and stability assessment of GLP-1 therapeutics
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