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For example, a methylene-linked oxetane increased potency 100-fold relative to the methyl substituent of 5 , leading to the identification of PF-06882961, which is a full agonist (EC 50 = 13 nM) in the CS cAMP assay (Fig
The medicines being considered for reclassification are typically those that treat common, self-limiting conditions or those where the risk can be managed with pharmacy intervention
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