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The first component, tirzepatide, is a dual GIP and GLP-1 receptor agonist that reduces appetite, slows gastric emptying, and improves insulin sensitivity
However, patients with decompensated cirrhosischaracterized by complications such as ascites, variceal bleeding, or hepatic encephalopathyrequire careful individualized assessment, as clinical trial data in this population remains limited
OhsawaYHagiwaraHNishimatsuSIHirakawaAKamimuraNOhtsuboHet al
Enhanced anastomotic strength could reduce leak rates following gastrointestinal surgery, while fistula healing effects might benefit patients with enterocutaneous or colocutaneous fistulas
In some, the SUOX gene is working slower than ideal
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