The second approach to detect LOXL2 activity specifically measures collagen IV 7S dodecamer crosslinks in the ECM by Western blotting 28,29,30
This makes it an effective therapy for various injuries such as tears, sprains, and strains
The translational pathway would benefit from early thoughts from materials science, clinical, and regulatory experts to co-design delivery formats (e.g., special nanocomposite antimicrobial coatings that rapidly kill persisters on catheters) and to co-plan staged clinical trials with microbiological markers of success (i.e., MBEC reduction and no relapse) and not just surrogates of colonization
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Fast, insured shipping and consistent inventory make it easier for labs to maintain continuity between projects, while detailed product descriptions give investigators the information they need to write precise methods sections for reports and manuscripts