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N-acetylcysteine, or NAC, is a modified version of L-cysteine

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In the phase 2 trial: Nausea was reported by approximately 40-60% of participants at higher doses, most common during the titration phase Vomiting occurred in roughly 20-30% at high doses Diarrhea was reported in around 20% of participants Constipation was less common than with semaglutide, appearing in roughly 10-15% Decreased appetite is technically a mechanism, but patients often report it as a side effect when it's more intense than expected The important caveat: the vast majority of GI side effects were mild to moderate in severity, and most resolved or significantly improved after the titration phase was complete