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Serine starvation inhibits the proliferation of colorectal cancer cells in in vitro (Labuschagne et al., 2014
It also lowered oxidative stress and damage in people with uncontrolled diabetes, despite high sugar levels
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In patients with hyperprolinemia, proline accumulation can cause a decrease in ATPase activity, which further leads to mitochondrial stress and elevated lactate levels, and can also decrease glutamate uptake [17]
However, they work through different mechanisms and can complement each other when used thoughtfully
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