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Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

Mechanism of Action GHK-Cu's biological activity appears to derive from two interconnected properties: copper transport and direct gene expression modulation

If gastrointestinal side effects (heartburn, nausea) are problematic, taking it with food may improve tolerability at the cost of reduced absorption

WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep out of reach of children

The cell index was defined as R n -R b at each time point of measurement, where R n is the cell-electrode impedance of the well when it contains cells, and R b is the background impedance of the well with the medium alone