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10.1136/thx.2009.126912 163
These include: Paraesthesia (pins and needles) in hands and feet Peripheral neuropathy with numbness or altered sensation Difficulty walking or balance problems (ataxia) Memory problems and cognitive difficulties Mood changes, including depression or irritability In severe cases, confusion or dementia-like symptoms Other manifestations may include: Loss of appetite and unintentional weight loss Constipation Visual disturbances (rare, but can occur with optic neuropathy) Important: The neurological complications of B12 deficiency can progress even in the absence of anaemia, making early detection crucial
Vitamin D, Calbindin, and calcium signaling: Unraveling the Alzheimers connection
Unlike arginine, citrulline bypasses first-pass metabolism in the liver, resulting in greater bioavailability and a more sustained increase in plasma arginine levels
There also would be interest in undertaking studies with GLP-1RAs such as semaglutide, designed to establish their effect on retardation of the atherosclerosis process along the lines of the studies carried out with pioglitazone, 1-3,12,13 which demonstrated slowing of the progression of carotid artery intimamedia thickness 15 and coronary artery atheroma
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