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GLP-1 medications slow gastric emptying, which often leads to nausea and vomiting, especially early in treatment
it does not by itself establish that medication is appropriate
Because this analysis cannot determine the cause of these differences, we dont know whether GLP1RAs help migraine directly, whether any improvements relate to broader effects such as better metabolic health, weight loss, or reduced inflammation, or whether the findings simply reflect the limitations of topiramate in realworld use
Congenital hypothyroidism is also caused by genetic manipulations, including mutations in TR genes in the rodent models (Gombik et al