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Neither is approved by Health Canada for human therapeutic use, and both appear on the WADA Prohibited List for sport

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It is classified as a Category 2 bulk drug substance by the FDA, which restricts its availability through compounding pharmacies

Neurology 52 , 12691271 (1999)

Appetite Effects The question about appetite is interesting because the proposed mechanism could reasonably go either direction: Reduced lipogenesis and improved metabolic flexibility could produce secondary effects on appetite regulation NAD+ restoration has complex effects on hypothalamic appetite signaling Preclinical data do not consistently describe dramatic appetite changes In human use were it to become clinically available patient-reported appetite effects would be a relevant monitoring parameter, but the data do not currently support a strong a priori expectation