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By combining GLP-1, GIP and glucagon receptor activity into a single weekly injection, it has the potential to deliver greater weight loss than current therapies while also improving blood sugar control, metabolic health and markers of cardiovascular and liver disease
When to Consult a Healthcare Professional While the combination of these two is generally safe, there are specific red flags that should prompt a conversation with your doctor
The SURMOUNT clinical trial programme showed average weight reductions exceeding 20% of body weight at the highest doses in some patient groups, which is notably higher than what the STEP trials showed for semaglutide
The most common side effects are gastrointestinal: nausea, fullness, constipation, diarrhea, reflux, and reduced appetite
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