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In a Phase IIb trial of 320 adults with obesity and biopsy-confirmed MASH and fibrosis stages F1F3, subcutaneous semaglutide (0.1 mg, 0.2 mg or 0.4 mg daily for 72 weeks) resulted in a significantly higher proportion of participants with MASH resolution without worsening of fibrosis than placebo (40%, 36% and 59% in participants treated with 0.1 mg, 0.2 mg or 0.4 mg daily, respectively, compared with 17% in the placebo group)

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Other side effects can include vomiting, headache, and dizziness

[Published online July 9, 2025] European Medicines Agency