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While gastrointestinal side effects remain common and manageable, higher doses have introduced new observations: Sensory disturbances (dysesthesia, paresthesia) Possible links to nutritional deficiencies (e.g., vitamin B12), though still debated Body Composition Matters Importantly, weight loss is not indiscriminate: ~85% fat mass reduction ~15% lean mass loss This underscores the importance of: Adequate protein intake Resistance training to preserve muscle mass Oral Semaglutide and Long-Term Maintenance Oral formulations (e.g., 25 mg semaglutide) offer a promising maintenance strategy: Weight reduction of ~1316 kg Easier long-term adherence compared to injectables The SNAC technology enables gastric absorption, though administration requires strict conditions (fasting, controlled water intake)

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Out-of-pocket costs for GLP-1 therapies can be substantial, often exceeding what many individuals can sustain over time

Many factors, such as diet, aging, or an underlying condition, can lead to insufficient or suboptimal levels of vitamins

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