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From a safety or side effect profile, I think the bigger concern is the side effect profile. The GLP-1s do have nausea and vomiting or gastrointestinal side effects, he said, which are usually more pronounced in the first month or two of therapy
People on certain medications including diuretics, beta-blockers, tricyclic antidepressants, and aspirin have heightened susceptibility
Your provider will evaluate your health details to recommend the best treatment pathway
Similar recommendations were made by the European Medicines Agency (EMA) that required including major adverse cardiovascular events (MACE) as a primary endpoint ( These regulatory requirements led to the discovery of cardiovascular benefits in GLP-1R agonists, demonstrating the importance of due diligence and proactive safety monitoring
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