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Discussion Here we show that zonula occludens toxin (Zot, or zonulin), a potent regulator for intestinal TJ competency and intestinal barrier function, is controlling the onset of murine and human arthritis
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Remarkably, an altered epithelial barrier function has been found in non-inflamed ileal regions in CD
This approach may simplify experimental preparation while allowing investigators to focus on study design, data collection, and analysis rather than sourcing individual peptide materials separately
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