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The standard escalation timeline is 16 weeksstarting at 0.25 mg and increasing every 4 weeks through 0.5 mg, 1.0 mg, 1.7 mg, and finally 2.4 mg
Definitions of the inclusion/exclusion criteria were based on diagnostic codes (i.e., International Classification of Disease [ICD] version 9 and 10) in the problem list, one inpatient encounter, at least two outpatient encounters within two years, or one procedure code which were provided in the supplement (eTable 1)
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