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Several researchers have proposed intranasal delivery to reduce first-pass degradation and allow direct olfactory-pathway CNS access
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The samples were amplified, hybridized onto the array, and subsequently stained
not for safety or efficacy guidance
In animal models the parent compound is described as relatively short-lived in plasma but with effects persisting longer than the systemic exposure window a profile the Zagreb group attributes to its stability in the gastrointestinal lumen and to downstream signaling cascades (Sikiric et al., 2018)
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