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Tirzepatide-based evidence from the SURPASS (Researching Tirzepatide in Patients with Type 2 Diabetes for Glycemic Control and Weight Management) trials (SURPASS-1 NCT03954834 and SURPASS-5 NCT04039503) demonstrated dose-dependent, significant weight loss over 40 weeks compared with placebo, along with reductions in BMI and waist circumference [62, 63]
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doi: 10.4161/gmic.2.2.15725 88 VavrickaSRMuschMWChangJENakagawaYPhanvijhitsiriKWaypaTSet al
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