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This indicated that, along with an overall decrease in TG synthesis, specific pathways/enzymes involved in polyunsaturated fatty acid (PUFA) synthesis may be stimulated in the livers of KO mice
J Dermatol 48(6):722731 Yamashita T, Kawashima S, Miwa Y, Ozaki M, Namiki M, Hirase T, Inoue N, Hirata K-I, Yokoyama M (2002) A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke-prone spontaneously hypertensive rats
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PGC1 is the master regulator of mitochondrial biogenesis 34 , and we see a small but sustained increase in PGC1 expression in response to 5FU over 72 h treatment (Fig
