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When to Hold a Dose Increase Escalation should only proceed if the current dose is well-tolerated
In addition, it includes comparisons of approved drugs, late-stage drugs and emerging oral obesity drugs
While their abilities to improve glycaemic control and promote weight loss are well established, increasing attention has focused on their potential to directly influence cardiovascular outcomes
For example, the FLOW trial demonstrated that GLP-1 medications can slow CKD progression and lower the risk of kidney failure
Retatrutide targets GLP-1, GIP, and glucagon receptors, making it the first triple agonist in its class and the primary reason for its superior weight loss results
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