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1 , a PDE-5 inhibitor attenuates the hydrolysis of cyclic guanosine monophosphate (cGMP, also called guanosine 3',5'-cyclic monophosphate), thereby increasing the persistence of cGMP, by inhibiting the activity of endogenous type V phosphodiesterase (PDE-5), it being understood that PDE-5 naturally regulates the degradation of cGMP to 5' guanosine monophosphate (5' GMP) in the corpus cavernosum
doi:10.1001/jama.2022.0078 51
