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39 As shown in the LEADER study (NCT01179048), the secondary composite outcome of persistent doubling of the serum creatinine level, new-onset persistent macroalbuminuria, end-stage renal disease or death due to renal disease occurred significantly less frequently in the treatment group than in the placebo group, with a hazard ratio of 0.78

While probiotics are generally considered safe for healthy individuals, serious adverse events can occur in specific populations, and certain symptoms warrant immediate medical evaluation

However, these medications are not yet available outside of research settings

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