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interestingly, this disadvantage is cell lineagespecific because it does not affect, for instance, fibroblasts

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They may be able to lower your dose, switch medications, or give you advice thats more specific to your personal needs

These pathways have simultaneously developed for organ-specific adaptation to meet the physiological demands specific to each organ, sensing glucose in pancreatic -cells for insulin secretion, and sensing various nutrients like amino acids, fatty acids, and glucose for GLP-1 secretion in intestinal L-cells 32

The GLP-1-producing preproglucagon (PPG) neurons located in the nucleus tractus solitarius (NTS) and the intermediate reticular nucleus of the medulla oblongata are the major source of endogenous GLP-1 in the central nervous system, which project widely throughout the central nervous system especially the autonomic control areas (Merchenthaler et al., 1999