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2022 NEJM) randomized 2,539 adults with overweight or obesity (without diabetes) to tirzepatide 5 mg, 10 mg, 15 mg, or placebo for 72 weeks

A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]

Generic and Patent Considerations Orforglipron's small-molecule nature has important implications for the patent landscape and the eventual emergence of generic competition

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