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In STEP 1 to 4.5% of participants discontinued due to gastrointestinal adverse events versus 0.8% on placebo [7]

You receive as much as you need for the best results

Verdict: Direct comparison difficult due to different trial designs, but retatrutide's advantage appears substantial even accounting for flexible vs fixed dosing

Slower Weight Loss: Clinical Considerations Patients with type 2 diabetes often see weight loss begin earlier (weeks 24) due to improved glycemic control and reduced caloric intake

This can be a temporary side effect as your body adapts to the medication, and energy levels may return to normal after the initial adjustment period