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Loss-of-function mutations or downregulation of genes encoding arGSTs result in strongly decreased accumulation of anthocyanins ( 1 ) in a wide range of plants 19,20,21,22,23,24,25,26,27,28 , including reduced fruit colouration in cultivated Fragaria vesca (strawberry) through transient knock-down of reduced anthocyanins in petioles ( RAP ) 20 or white Prunus persica (peach) flowers caused by an arGST encoding regulator involved in anthocyanin transport ( Riant ) gene with a 2 bp insertion leading to a premature stop codon 21

Wu F, Liu Y, Zhang M, Yuan X, Jin Y, Li Y, Wang R, Hao Y, Fang B (2025) Effects of 1,3-dioleoyl-2-palmitoylglycerol on intestine structural and functional development in early life

These findings align with the cuprizone-induced demyelination shown earlier (25)

Understanding this effect allows for better dosing, closer monitoring, and more confident use of these powerful metabolic tools

Semaglutide should not be used concurrently with other GLP-1 receptor agonists or tirzepatide