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Berberine GI side effects in clinical trials affect 10 to 35% of users, with diarrhea reported specifically in 15 to 25% of those taking 1000 to 1500mg daily
This troubling gap prevents evaluation of methodology or potential adverse findings that might have prompted withholding publication
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1) revealed substitutions at the known DPP-4 cleavage site (Ala 8 in human) to Ser or Phe in platypus and echidna respectively, predicting that DPP-4 cleavage could be affected
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