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JAMA 2001;285:785-95
This is a big hit to the thesis, but Novo has two other trials ongoing with IL6 blockade (one in patients with heart failure, the other in patients hospitalized with myocardial infarction) and inhibition of the pathway upstream by hitting NLRP3, a constituent of the inflammasome is being tested by many teams, too
These treatments could broaden adoption by appealing to patients who prefer to avoid injections and by enabling more scalable manufacturing
The medical community, including the FDA, does not officially recognize this condition
Understanding the difference is important for appropriate management
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