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The TRIUMPH-4 Phase 3 data provides the most current safety information: Nausea: 38.1% (9 mg) to 43.2% (12 mg) versus 10.7% placebo Diarrhea: 34.7% (9 mg) to 33.1% (12 mg) versus 13.4% placebo Constipation: 21.8% (9 mg) to 25.0% (12 mg) versus 8.7% placebo Vomiting: 20.4% (9 mg) to 20.9% (12 mg) versus 0% placebo Decreased appetite: 19.0% (9 mg) to 18.2% (12 mg) versus 9.4% placebo The pattern is clear

It may also increase calorie burning, though the human evidence for this is still mixed

Instead, the Lancet Commission is looking to define more appropriate, scientifically sound and pragmatic criteria for the diagnosis of clinical obesity as a disease state, not a risk factor

Ferri, N

A licensed provider then reviews the submitted information and determines whether treatment is appropriate for the individual patient