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Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials
Degradation of sex pheromone and plant volatile components by an antennal glutathione S-transferase in the oriental fruit moth, Grapholita molesta Busck (Lepidoptera: Tortricidae)
In the foundational study by Raun et al
[Internet]
This pattern holds biological significance in PD in that it suggests that disease- or treatment-related effects may exert selective pressure on the microbial network in the gut without necessarily lowering the overall number of microbial species present, thereby exerting an influence on GBA signaling and L-DOPA metabolism
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