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Given that fluoropyrimidine-based therapy will remain a major treatment modality for patients with advanced CRC for the foreseeable future, the need for better, more effective chemotherapy combinations in biologically selected populations to overcome drug resistance is an urgent, unmet need for patients with CRC worldwide

1b) and thereby interfere with ICS biosynthesis which in turn can have an impact on the development of cancer

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Consistent with enhanced glutathione production, melatonin-treated ILC2s exhibited increased expression of GCLC and GCLM, enzymes that catalyze the rate-limiting steps in glutathione synthesis ( Figures 6E, F )

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