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By combining peripheral effects (slower gastric emptying, metabolic adjustments) with central nervous system actions (reduced hunger and altered food reward), GLP-1 RAs produce sustained reductions in caloric intake and clinically meaningful weight loss
PubMed CrossRef Volkow ND, Xu R
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It is susceptible to carboxypeptidase cleavage, light-driven copper photo-oxidation and pH extremes, with an optimum of about 5.0 to 6.5
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