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& Portenoy, R

The injectable data is from rigorous randomized controlled trials

However, researchers believe that more large-scale studies are needed to fully prove these initial positive results

A 2005 study demonstrated that both peptide and non-peptide GH secretagogues act through the GHS-R1a receptor but can also function as ghrelin receptor ligands with distinct binding properties, suggesting potential differences in downstream signaling despite shared receptor engagement

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