It happens because the medication becomes too expensive, insurance coverage changes, supply gets inconsistent or the side effects become too much to manage
The fasting requirement and water restriction were monitored in the trial setting

Des-Glu15-Semaglutide - Request Quote Des-Glu15-Semaglutide Chemical Name : Shipping Temperature : HSN Code : Country of Origin : Smiles : CHNS Ratio (%) : Usage Note : Des-Glu15-Semaglutide is chemically (3S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,42S,45S,48S,51S,78R)-51-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-3-(2-((S)-2-amino-3-(1H-imidazol-5-yl)propanamido)-2-methylpropanamido)-42-(3-amino-3-oxopropyl)-12-benzyl-21-(carboxymethyl)-33-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27,30-tris(hydroxymethyl)-36-isobutyl-24-isopropyl-45,48-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,57,66,75,80-icosaoxo-59,62,68,71-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,56,65,74,79-icosaazahexanonacontane-1,78,96-tricarboxylic acid

That is why we built a program around the injection, not just the injection itself
Medicare covers days 1 through 60 fully after the deductible, then charges $419 per day for days 61 through 90